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Bioprocess Engineering-Basic Concepts by Shuler and Kargi: A Review
Bioprocess Engineering-Basic Concepts by Shuler and Kargi is a textbook that covers the fundamentals of biochemical and bioprocess engineering. It is intended for undergraduate and graduate students who are interested in learning about the principles and applications of biotechnology. The book is divided into four parts: The Basics of Biology: An Engineer's Perspective, Enzyme Kinetics and Reactor Design, Cell Growth and Product Formation, and Bioprocess Considerations.
The first part introduces the basic concepts of biochemistry, microbiology, and molecular biology that are relevant for bioprocess engineering. It covers topics such as enzymes, cell functions and growth, metabolic pathways, genetic engineering, and recombinant DNA technology. The second part focuses on enzyme kinetics and reactor design, including enzyme inhibition and activation, immobilized enzymes, batch and continuous reactors, and biocatalysis. The third part deals with cell growth and product formation, including population balances, batch and fed-batch cultures, continuous cultures, animal and plant cell cultures, recombinant protein production, and metabolic engineering. The fourth part discusses bioprocess considerations, such as sterilization, aseptic operations, bioreactor design and analysis, downstream processing, biosensors, biofuels, synthetic biology, and bioprocess safety.
The book is well-written and organized, with clear explanations, examples, problems, figures, tables, and references. It also includes an appendix that describes traditional bioprocesses such as brewing, cheese making, vinegar production, etc. The book is suitable for students who have a background in mathematics, physics, chemistry, and engineering. It provides a comprehensive and up-to-date overview of the field of bioprocess engineering.Some of the applications of bioprocess engineering are:
Pharmaceuticals: Bioprocess engineers work in pharmaceutical research and development to study and test chemical and biological processes that help create medicines that are safe and effective. They also design and optimize bioreactors, fermentation processes, purification methods, and quality control systems for the production of drugs, vaccines, hormones, antibodies, and other biopharmaceuticals[^1^].
Biomedicine: Bioprocess engineering also encompasses medical applications, such as tissue engineering, gene therapy, stem cell technology, biosensors, artificial organs, and nanotechnology. Bioprocess engineers use their knowledge of biomaterials, biocompatibility, cell culture, bioreactor design, and bioprocessing to create novel solutions for the diagnosis, treatment, and prevention of diseases[^1^] [^2^].
Agriculture and food production: Agricultural applications that rely on bioprocess engineering include food production and commercial farming. Bioprocess engineers use genetic engineering, metabolic engineering, enzyme engineering, and biocatalysis to improve the yield, quality, and nutritional value of crops and animal products. They also develop biofuels, bioplastics, biofertilizers, biopesticides, and other bioproducts from renewable resources[^1^] [^3^].
Conservation: Bioprocess engineering also contributes to environmental conservation and sustainability. Bioprocess engineers design and operate bioremediation systems that use microorganisms or enzymes to degrade pollutants and contaminants in soil and water. They also develop biosensors and bioassays that monitor environmental quality and detect hazardous substances. They also apply bioprocess engineering principles to reduce waste generation and energy consumption in industrial processes[^1^] [^4^]. 061ffe29dd